CENTER ON BEHAVIORAL MEDICINE
Psychoneuroendocrine: Research Article
JM Martins, J.M., et al. (2001) Psychoneuroendocrine
of common obesity clinical subtypes. International Journal of
Obesity (2001) 25, 24▒32.
Objective: To relate psychological pro«les, cerebral asymmetry and the hypothalamus ▒ pituitary ▒ adrenal axis (HPA) reactivity to clinical characteristics of common obesity.
Methods: Sixty consecutive adult female overweight and obese patients attending the outpatient endocrine department were included in this study. Clinical evaluation speci«cally selected a priori the following indexes: obesity age of onset, parenthood obesity, carbohydrate craving, binge eating with purging, obesity degree (de«ned by the body mass index (BMI)đweight (kg)=height (m2)), body fat distribution (de«ned by the abdominal ▒ thigh ratio (A=T)) and initial weight loss after medical treatment. Psychological evaluation was performed with the Minnesota Multiphasic Personality Inventory (MMPI). In the last 30 patients, the Edinburgh Inventory of Manual Preference (EIMP) and the corticotrophin-releasing hormone (CRH) test were also performed.
Results: Clinical characteristics
a priori were independent variables as evaluated by contingency table
Factorial analysis of variance (ANOVA) revealed a signi«cantly
MMPI pro«le, according to parental obesity, with posthoc
higher scores on the hypochondriasis (Hs), paranoia (Pa), psychasthenia
(Pt) and schizophrenia (Sc) scales in patients with obese parents.
patients presented signi«cantly higher dichotomized manual
indexes in relation to overweight patients. Parental obesity, binge
behaviour with purging, body fat distribution and the dichotomized
Conclusions: Overweight=obese subjects with parental obesity present a distinctive personality pro«le and a higher ACTH response in the CRH test. Cerebral asymmetry may be a relevant factor for obesity development and is associated with the HPA reactivity. HPA reactivity is a sensitive index integrating clinical, psychological and neural asymmetric factors.
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