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Genetic Influences of Vulnerability to Alcoholism and Affective Disorder

CITATION:  Nurnberger, J.I. (2001). Evidence for a Locus on Chromosome 1 That Influences Vulnerability to Alcoholism and Affective Disorder. Am J Psychiatry 158:718–724.

ABSTRACT:  Depression (major depression or depressive syndrome) is more prevalent in alcoholic than in nonalcoholic subjects in families with multiple members with alcoholism studied as part of the Collaborative Study on the Genetics of Alcoholism (National Institute on Alcohol Abuse and Alcoholism). First-degree relatives of probands with comorbid alcoholism and depression have a higher prevalence of both disorders than relatives of probands with alcoholism alone, and both groups have a higher prevalence than the relatives of comparison subjects selected without regard to psychopathology.

The results suggest that a gene or genes on chromosome 1 may predispose some individuals to alcoholism and others to depression (which may be alcohol induced). Loci on other chromosomes may also be of interest. 

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