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Gene-environment Interplay in Relations to Emotional and  Behavioral Disturbance

CITATION:  Rutter, M., Silberg, J., (2002).  Gene-environment interplay in relations to emotional and  behavioral disturbance.  Annual Review of Psychology, 53, pp. 463-90, 2002.  

ABSTRACT:  The conceptual and methodological issues involved in the study of gene-environment correlations (rGE) and interactions (GxE) are discussed in historical context. Quantitative genetic findings are considered with respect to rGE and GxE in relation to emotional and behavioral disturbance. Key conceptual and substantive implications are outlined in relation to both genetic and environmental risk mediation, with a brief note on evolutionary considerations.


Angold A, Costello EJ, Erkanli A, Worthman CH. 1999. Pubertal changes in hormone levels and depression in girls. Psychol. Med. 29:1043-53

Anisman H, Zaharia MD, Meaney MJ, Merali Z. 1998. Do early-life events permanently alter behavioral and hormonal responses to stressors? Int. J. Dev. Neurosci. 16:149-64

Bateson P, Martin P. 1999. Design for a Life: How Behaviour Develops. London: Cape

Bell RQ. 1968. A reinterpretation of the direction of effects in studies of socialization. Psychol. Rev. 75:81-95

Bell RQ, Chapman M. 1986. Child effects in studies using experimental or brief longitudinal approaches to socialization. Dev. Psychol. 22:595-603

Billig JP, Hershberger SL, Iacono WG. McGue M. 1996. Life events and personality in late adolescence: genetic and environmental relations. Behav. Genet. 26:543-54

Birley AJ, MacLennan R, Wahlqvist M, Gerns L, Pangan T, et al. 1997. MN blood group affects response of serum LDL cholesterol level to a low fat diet. Clin. Genet. 51:291-95

Bock GR, Goode J, Webb K, eds. 2000. The Nature of Intelligence. London: Wiley

Bodmer WF, Cavalli-Sforza LL. 1976. Genetics, Evolution, and Man. San Francisco: Freeman

Bohman M. 1996. Predisposition to criminality: Swedish adoption studies in retrospect. In Genetics of Criminal and Antisocial Behaviour. Ciba Found. Symp. 194, ed. GR Bock, JA Goode, pp. 99-114. 
Chichester, UK: Wiley

Boomsma DI, de Geus EJC, van Baal GCM, Koopmans JR. 1999. A religious upbringing reduces the influence of genetic factors on disinhibition: evidence for interaction between genotype and environment on personality. Twin Res. 2:115-25

Bronfenbrenner U, Ceci SJ. 1994. Naturenurture reconceptualization in developmental perspective: a bioecological model. Psychol. Rev. 101:568-86

Brown GW, Harris TO, Lemyre L. 1991. Now you see it, now you don't--some considerations on multiple regression. In Problems and Methods in Longitudinal Research: Stability and Change, ed. D Magnusson, LR Bergman, G Rudinger, B Törestad, pp. 67-94. Cambridge: Cambridge Univ. Press

Brussoni MJ, Jang KL, Livesley WJ, Macbeth TM. 2000. Genetic and environmental influences on adult attachment styles. Pers. Relat. 7:283-89

Busjahn A, Faulhaber H-D, Freier K, Luft FC. 1999. Genetic and environmental influences on coping styles: a twin study. Psychosom. Med. 61:469-75

Cadoret RJ, Cain C. 1980. Sex differences in predictors of antisocial behavior in adoptees. Arch. Gen. Psychiatry 37:1171-75

Cadoret RJ, Cain CA, Crowe RR. 1983. Evidence for gene-environment interaction in the development of adolescent antisocial behavior. Behav. Genet. 13:301-10

Cadoret RJ, Troughton E, O'Gorman TW. 1987. Genetic and environmental factors in alcohol abuse and antisocial personality. J. Stud. Alcohol 48:1-8

Cadoret RJ, Winokur G, Langbehn D, Troughton E. Yates WR, et al. 1996. Depression spectrum disease. I. The role of gene-environment interaction. Am. J. Psychiatry 153:892-99

Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MAS. 1995. Geneticenvironmental interaction in the genesis of aggressivity and conduct disorders. Arch. Gen. Psychiatry 52:916-24

Carbonneau R, Eaves LJ, Silberg JL, Hewitt JK, Simonoff E, et al. 2001. Assessment of the Within Family Environment in Twins: Absolute versus Differential Ratings, and Relationship with Conduct Problems. Submitted

Cattell RB. 1965. Methodological and conceptual advances in evaluating hereditary and environmental influences and their interaction. In Methods and Goals in Human Behavior Genetics, ed. SG Vandenberg, pp. 95-139. New York: Academic

Cavalli-Sforza LL, Feldman MW. 1973. Models for cultural inheritance. I. Group mean and within group variation. Theor. Popul. Biol. 4:42-55

Chadwick D, Cardew G, eds. 1996. Variation in the Human Genome. Ciba Found. Symp. 197. Chichester, UK/New York: Wiley

Champion LA, Goodall GM, Rutter M. 1995. Behavioural problems in childhood and stressors in early adult life: A 20-year follow-up of London school children. Psychol. Med. 25:231-46

Chandra V, Pandav R. 1998. Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol. Neuroepidemiology 17:225-32

Crowe RR. 1974. An adoption study of antisocial personality. Arch. Gen. Psychiatry 31:785-91

Davies SC, Brozovic M. 1989. The presentation, management and prophylaxis of sickle cell disease. Blood Rev. 3:29-44

Dawkins R. 1982. The Extended Phenotype: The Gene as the Unit of Selection. Oxford: Oxford Univ. Press

Dawkins R. 1989. The Selfish Gene. Oxford: Oxford Univ. Press. 2nd ed.

Deater-Deckard K, Fulker DW, Plomin R. 1999. A genetic study of the family environment in the transition to early adolescence. J. Child Psychol. Psychiatry 40:769-75

Deater-Deckard K, O'Connor TG. 2000. Parent-child mutuality in early childhood: two behavioral genetic studies. Dev. Psychol. 36:561-70

DeFries JC, Fulker DW. 1985. Multiple regression analysis of twin data. Behav. Genet. 5:467-73

Dick DM, Rose RJ, Viken RJ, Kaprio J, Koskenvuo M. 2001. Exploring gene-environment interactions: socio-regional moderation of alcohol use. J. Abnorm. Psychol. In press

Dickens WT, Flynn JR. 2001. Heritability estimates vs. large environmental effects: the IQ paradox resolved. Psychol. Rev. 108:346-69

Dunne MP, Martin NG, Statham DJ, Slutske WS, Dinwiddie SH, et al. 1997. Genetic and environmental contributions to variance in age at first sexual intercourse. Psychol. Sci. 8:211-16

Durham WH. 1991. Co-Evolution: Genes, Culture and Human Diversity. Stanford, CA: Stanford Univ. Press 

Eaves L, Erkanli A. 2001. Markov Chain Monte Carlo Approaches to Analysis of Genetic and Environmental Components of Human Developmental Change and GxE Interaction. Submitted

Eaves LJ. 1976a. The effect of cultural transmission on continuous variation. Heredity 37:41-57

Eaves LJ. 1976b. A model for sibling effects in man. Heredity 36:205-14

Eaves LJ. 1984. The resolution of genotype x environment interaction in segregation analysis of nuclear families. Genet. Epidemiol. 1:215-28

Eaves LJ, Eysenck HJ. 1977. A genotype-environmental model for psychoticism. Adv. Behav. Res. Ther. 1:5-26

Eaves LJ, Last KA, Martin NG, Jinks JL. 1977. A progressive approach to non-additivity and genotype-environmental covariance in the analysis of human differences. Br. J. Math. Stat. Psychol. 30:1-42

Elkins IJ, McGue M, Iacono WG. 1997. Genetic and environmental influences on parent-son relationships: evidence for increasing genetic influence during adolescence. Dev. Psychol. 33:351-63

Engfer A, Walper S, Rutter M. 1994. Individual characteristics as a force in development. In Development Through Life: A Handbook for Clinicians, ed. M Rutter, DF Hay, pp. 79-111. Oxford: Blackwell Sci.

Evans WE, Relling MV. 1999. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286:487-91

Flynn JR. 2000. IQ gains, WISC subtests and fluid g: g theory and the relevance of Spearman's hypothesis to race. In The Nature of Intelligence. Novartis Found. Symp. 233, ed. GR Bock, JA Goode, K Webb, pp. 202-16. Chichester, Engl: Wiley

Ge X, Conger RD, Cadoret RJ, Neiderhiser JM, Yates W, et al. 1996. The developmental interface between nature and nurture: a mutual influence model of child antisocial behavior and parenting. Dev. Psychol. 32:574-89

Haley CS, Jinks JL, Last KA. 1981. The monozygotic twin half-sib method for analysing maternal effects and sex linkage in humans. Heredity 46:227-38

Heath AC, Berg K, Eaves LJ, Solaas MH, Corey LA, et al. 1985. Education and policy and the heritability of educational attainment. Nature 314:734-36

Heath AC, Cates R, Martin NG, Meyer J, Hewitt JK, et al. 1993. Genetic contribution to risk of smoking initiation: comparisons across birth cohorts and across cultures. J. Subst. Abuse 5:221-46

Heath AC, Eaves LJ, Martin NG. 1998. Interaction of marital status and genetic risk for symptoms of depression. Twin Res. 1:119-22

Heath AC, Jardine R, Martin NG. 1989. Interactive effects of genotype and social environment on alcohol consumption in female twins. J. Stud. Alcohol 50:38-48

Hill AVS. 1998. The immunogenetics of human infectious diseases. Annu. Rev. Immunol. 16:593-617

Humphries SE, Talmud PJ, Bolla M, Cooper J, Day INM, et al. 2001. Apolipoprotein E and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet 358:115-19

Hur Y-M, McGue M, Iacono WG. 1996. Genetic and shared environmental influences on leisure-time interests in male adolescents. Pers. Individ. Differ. 21:791-801

Jensen AR. 1973. Educability and Group Differences. New York: Harper & Row

Jensen AR. 1997. The puzzle of nongenetic variance. In Intelligence, Heredity, and Environment, ed. RJ Sternberg, EL Grigorenko, pp. 42-88. Cambridge: Cambridge Univ. Press

Jinks JL, Fulker DW. 1970. Comparison of the biometrical genetical, MAVA and classical approaches to the analysis of human behavior. Psychol. Bull. 73:311-49

Jockin V, McGue M, Lykken DT. 1996. Personality and divorce: a genetic analysis. J. Pers. Soc. Psychol. 71:288-99

Jones HE. 1946. Environmental influences on mental development. In Manual of Child Psychology. ed. L Carmichael, pp. 582-632. New York: Wiley

Kendler KS, Eaves LJ. 1986. Models for the joint effect of genotype and environment on liability to psychiatric illness. Am. J. Psychiatry 143:279-89

Kendler KS, Gardener CO. 1998. Twin studies of adult psychiatric and substance dependence disorders: Are they biased by differences in the environmental experience of mono- and dizygotic twins in childhood and adolescence? Psychol. Med. 28:625-33

Kendler KS, Gardner CO. 2001. Monozygotic twins discordant for major depression: a preliminary exploration of the role of environmental experiences in the aetiology and course of illness. Psychol. Med. 31:411-23

Kendler KS, Gardner CO, Prescott CA. 2001. Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychol. Med. 31:605-16

Kendler KS, Karkowski LM, Prescott CA. 1999. Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry 156:837-41

Kendler KS, Karkowski-Shuman L. 1997. Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychol. Med. 27:539-47

Kendler KS, Kessler RC, Walters EE, MacLean C, Neale MC, et al. 1995. Stressful life events, genetic liability, and onset of an episode of major depression in women. Am. J. Psychiatry 152:833-42

Kendler KS, Neale M, Kessler R, Heath A, Eaves L. 1993. A twin study of recent life events and difficulties. Arch. Gen. Psychiatry 50:789-96

Kendler KS, Neale MC, Kessler RC, Eaves LJ. 1994. Parental treatment and the equal environment assumption in twin studies of psychiatric illness. Psychol. Med. 24:579-90

Kendler KS, Neale MC, Prescott CA, Kessler RC, Heath AC, et al. 1996. Childhood parental loss and alcoholism in women: a causal analysis using a twin-family design. Psychol. Med. 26:79-95

Kendler KS, Thornton LM, Pedersen NL. 2000. Tobacco consumption in Swedish twins reared apart and reared together. Arch. Gen. Psychiatry 57:886-92

Knight JC, Udalova I, Hill AVS, Greenwood BM, Peshu N, et al. 1999. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat. Genet. 22:145-50

Koeppen-Schomerus G, Eley TC, Wolke D, Gringras P, Plomin R. 2000. The interaction of prematurity with genetic and environmental influences on cognitive development in twins. J. Pediatr. 137:527-33

Koopmans JR, Slutske WS, van Baal GCM, Boomsma DI. 1999. The influence of religion on alcohol use initiation: evidence for genotype X environment interaction. Behav. Genet. 29:445-53

Legrand LN, McGue M, Iacono WG. 1999. Searching for interactive effects in the etiology of early-onset substance use. Behav. Genet. 29:433-44

Lehrman DS. 1965. Interaction between internal and external environments in the regulation of the reproductive cycle of the ring dove. In Sex and Behavior, ed. FA Beach, pp. 355-80. New York: Wiley

Loehlin J. 1965. Some methodological problems in Cattell's Multiple Abstract Variance Analysis. Psychol. Rev. 72:156-61

Maccoby EE, Jacklin CN. 1983. The "person" characteristics of children and the family as environment. See Magnusson & Allen 1983, pp. 76-91

Maciejewski PK, Prigerson HG, Mazure CM. 2000. Sex differences in event-related risk for major depression. Psychol. Med. 31:593-604

Mackay TFC. 2001. Quantitative trait loci in drosophila. Nat. Rev. 2:11-20

Magnusson D, Allen VL, eds. 1983. Human Development: An Interactional Perspective. New York: Academic 

Mather K, Jinks JL. 1982. Biometrical Genetics: The Study of Continuous Variation. London: Chapman & Hall

Mayeux R, Ottman R, Maestre G, Ngai C, Tang M-X, et al. 1995. Synergistic effects of traumatic head injury and apolipoprotein-epsilon4 in patients with Alzheimer's disease. Neurology 45:555-57

McClearn GE, Vogler GP, Hofer SM. 2001. Environment-gene and gene-gene interactions. In Handbook of the Biology of Aging, ed. EJ Masoro, SN Austad, pp. 423-44. San Diego, CA: Academic. 5th ed.

McGue M, Lykken DT. 1992. Genetic influence on risk of divorce. Psychol. Sci. 3:368-73

Meyer JM, Rutter M, Silberg JL, Maes HH, Simonoff E, et al. 2000. Familial aggregation for conduct disorder symptomatology: the role of genes, marital discord and family adaptability. Psychol. Med. 30:759-74

Minihane AM, Khan S, Leigh Firbank EC, Talmud P, Wright JW, et al. 2000. ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler. Thromb. Vasc. Biol. 20:1990-97

Molenaar PCM, Boomsma DI, Dolan CV. 1993. A third source of developmental differences. Behav. Genet. 23:519-24

Molenaar PCM, Boomsma DI, Dolan CV. 1999. The detection of genotype-environment interaction in longitudinal genetic models. In On the Way to Individuality: Methodological Issues in Behavioral Genetics, ed. M LaBuda, E Grigorenko, pp. 53-70. New York: Nova Sci.

Murray L, Cooper PJ, eds. 1997. Postpartum Depression and Child Development. New York: Guilford

Nance WE, Kramer AA, Corey LA. Winter P, Eaves LJ. 1983. A causal analysis of birth weight in the offspring of monozygotic twins. Am. J. Hum. Genet. 35:1211-23

Neiderhiser JM, Reiss D, Hetherington EM, Plomin R. 1999. Relationships between parenting and adolescent adjustment over time: genetic and environmental contributions. Dev. Psychol. 5:680-92

O'Connor TG, Caspi A, DeFries JC, Plomin R. 2000. Are associations between parental divorce and children's adjustment genetically mediated? An adoption study. Dev. Psychol. 36:429-37

O'Connor TG, Deater-Deckard K, Fulker D, Rutter M. Plomin R. 1998. Genotype-environment correlations in late childhood and early adolescence: antisocial behavioral problems and coercive parenting. Dev. Psychol. 34:970-81

O'Connor TG, Hetherington EM, Reiss D, Plomin R. 1995. A twin-sibling study of observed parent-adolescent interactions. Child Dev. 66:812-29

Odling-Smee FJ. 1996. Niche construction, genetic evolution and cultural change. Behav. Process. 35:195-205

Ottman R. 1996. Gene-environment interaction: definitions and study designs. Prev. Med. 25:764-70

Pérusse D, Neale MC, Heath AC, Eaves LJ. 1994. Human parental behavior: evidence for genetic influence and potential implication for gene-culture transmission. Behav Genet. 24:327-35

Petitto JM, Evans DL. 1999. Clinical neuroimmunology. In Neurobiology of Mental Illness, ed. DS Charney, EJ Nestler, BS Bunney, pp. 162-69. New York: Oxford Univ. Press

Petronis A. 2001. Human morbid genetics revisited: relevance of epigenetics. Trends Genet. 17:142-46

Pickles A. 1993. Stages, precursors and causes in development. In Precursors and Causes in Development and Psychopathology, ed. DF Hay. A Angold, pp. 23-49. Chichester, UK: Wiley

Pike A, Manke B, Reiss D, Plomin R. 2000. A genetic analysis of differential experiences of adolescent 
siblings across three years. Soc. Dev. 9:96-114

Pike A. McGuire S, Hetherington EM, Reiss D, Plomin R. 1996. Family environment and adolescent depressive symptoms and antisocial behavior: a multivariate genetic analysis. Dev. Psychol. 32:590-603

Plassman BL, Breitner JCS. 1996. Recent advances in the genetics of Alzheimer's disease and vascular dementia with an emphasis on gene-environment interactions. J. Am. Geriatr. Soc. 44:1242-50

Plomin R. 1994. Genetics and Experience: The Interplay Between Nature and Nurture. Thousand Oaks, CA: Sage

Plomin R, Bergeman CS. 1991. The nature of nurture: genetic influence on 'environmental' measures. Behav. Brain Sci. 10:373-427

Plomin R, Crabbe J. 2000. DNA. Psychol. Bull. 126:806-28

Plomin R, Daniels D. 1987. Why are children in the same family so different from each other? Behav. Brain Sci. 10:1-16

Plomin R, DeFries JC. Fulker DW. 1988. Nature and Nurture During Infancy and Early Childhood. New York: Cambridge Univ. Press

Plomin R. DeFries JC, Loehlin JC. 1977. Genotype-environment interaction and correlation in the analysis of human behavior. Psychol. Bull. 84:309-22

Plomin R, Lichtenstein P, Pedersen NL, McClearn GE, Nesselroade JR. 1990. Genetic influence on life events during the last half of the life span. Psychol. Aging 5:25-30

Plomin R, Reiss D, Hetherington EM, Howe GW. 1994. Nature and nurture: genetic contributions to measures of the family environment. Dev. Psychol. 30:32-43

Plomin R, Rutter M. 1998. Child development, molecular genetics, and what to do with genes once they are found. Child Dev. 69:1223-42

Quinton D, Pickles A, Maughan B, Rutter M. 1993. Partners, peers, and pathways: assortative pairing and continuities in conduct disorder. Dev. Psychopathol. 5:763-83

Rao DC, Morton NE, Yee S. 1976. Resolution of cultural and biological inheritance by path analysis. Am. J. Hum. Genet. 26:331-59

Reed TE. 1985. Ethnic differences in alcohol use, abuse, and sensitivity: a review with genetic interpretation. Soc. Biol. 32:195-209

Reiss D, Hetherington EM, Plomin R, Howe GW, Simmens SJ, et al. 1995. Genetic questions for environmental studies: differential parenting and psychopathology in adolescence. Arch. Gen. Psychiatry 52:925-36

Reiss D, Neiderhiser JM, Hetherington EM, Plomin R. 2000. The Relationship Code: Deciphering Genetic and Social Influences on Adolescent Development. Cambridge, MA: Harvard Univ. Press

Rice J, Cloninger CR, Reich T. 1978. Multifactorial inheritance with cultural transmission and assortative mating. I. Description and basic properties of the unitary models. Am. J. Hum. Genet. 30:618-43

Riggins-Caspers K, Cadoret RJ, Panak W, Lempers JD, Troughton E, et al. 1999. Gene x environment interaction and the moderating effect of adoption agency disclosure on estimating genetic effects. Pers. Individ. Differ. 27:357-80

Robins L. 1966. Deviant Children Grown Up: A Sociological and Psychiatric Study of Sociopathic Personality. Baltimore: Williams & Wilkins

Rose S. 1995. The rise of neurogenetic determinism. Nature 373:380-82

Rose S. 1998. Lifelines: Biology, Freedom, Determinism. Harmondsworth, UK: Penguin

Rose RJ, Dick DM, Viken RJ, Kaprio J. 2001. Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use. Alcohol. Clin. Exp. Res. 25:637-43

Rowe DC, Jacobson KC, van den Oord EJCG. 1999. Genetic and environmental influences on vocabulary IQ: parental education level as moderator. Child Dev. 70:1151-62

Rubinzstein DC. 1995. Apolipoprotein E: a review of its roles in lipoprotein metabolism, neuronal growth and repair, and as a risk factor for Alzheimer's disease. Psychol. Med. 25:223-99

Rutter M. 1983. Statistical and personal interactions: facets and perspectives. See Magnusson & Allen 1983, pp. 295-319

Rutter M. 1987. Continuities and discontinuities from infancy. In Handbook of Infant Development, ed. J 
Osofsky, pp. 1256-96. New York: Wiley. 2nd ed.

Rutter M. 1989. Psychiatric disorder in parents as a risk factor for children. In Prevention of Mental Disorders, Alcohol and Other Drug Use in Children and Adolescents. OSAP Prevention Monogr. 2, ed. D Shaffer, I Philips, NB Enzer, pp. 157-89. Rockville, MD: Off. Subst. Abuse Prev., US Dep. Health Hum. Serv.

Rutter M. 1997. Comorbidity: concepts, claims and choices. Crim. Behav. Mental Health 7:265-85

Rutter M. 2000a. Psychosocial influences: critiques, findings, and research needs. Dev. Psychopathol. 12:375-405

Rutter M. 2000b. Resilience reconsidered: conceptual considerations, empirical findings, and policy implications. In Handbook of Early Childhood Intervention, ed. JP Shonkoff, SJ Meisels, pp. 651-82. New York: Cambridge Univ. Press

Rutter M. 2000c. Negative life events and family negativity. In Where Inner and Outer Worlds Meet: Psychosocial Research in the Tradition of George W Brown, ed. T Harris, pp. 123-49. London: Routledge

Rutter M. 2001a. Genetic influences and risk reduction: implications for understanding resilience. In Resilience and Vulnerability: Adaptation in the Context of Childhood Adversities, ed. SS Luthar. New York: Cambridge Univ. Press. In press

Rutter M. 2001b. Nature, nurture and development: from evangelism through science towards policy and practice. Child Dev. In press

Rutter M, Champion L, Quinton D, Maughan B, Pickles A. 1995. Understanding individual differences in environmental risk exposure. In Examining Lives in Context: Perspectives on the Ecology of Human Development, ed. P Moen, GH Elder Jr, K Lüscher, pp. 61-93. Washington, DC: Am. Psychol. Assoc.

Rutter M, Dunn J, Plomin R, Simonoff E, Pickles A. et al. 1997a. Integrating nature and nurture: implications of person-environment correlations and interactions for developmental psychology. Dev. Psychopathol. 9:335-64

Rutter M, Giller H, Hagell A. 1998. Antisocial Behavior by Young People. New York: Cambridge Univ. Press

Rutter M, Maughan B, Meyer J, Pickles A, Silberg J, et al. 1997b. Heterogeneity of antisocial behavior: causes, continuities, and consequences. In Nebraska Symposium on Motivation, Vol. 44. Motivation and Delinquency, ed. R Dienstbier, DW Osgood, pp. 45-118. Lincoln: Univ. Neb. Press

Rutter M, Pickles A. 1991. Person-environment interactions: concepts, mechanisms and implications for data analysis. In Conceptualization and Measurement of Organism-Emironment Interaction, ed. TD Wachs, R Plomin, pp. 105-41. Washington, DC: Am. Psychol. Assoc.

Rutter M, Pickles A, Murray R, Eaves L. 2001. Testing hypotheses on specific environmental causal effects on behavior. Psychol. Bull. 127:291-324

Rutter M, Plomin R. 1997. Opportunities for psychiatry from genetic findings. Br. J. Psychiatry 171:209-19

Rutter M, Silberg J, O'Connor T, Simonoff E. 1999a. Genetics and child psychiatry. I. Advances in quantitative and molecular genetics. J. Child Psychol. Psychiatry 40:3-18

Rutter M, Silberg J, O'Connor T, Simonoff E. 1999b. Genetics and child psychiatry. II. Empirical research findings. J. Child Psychol. Psychiatry 40:19-55

Rutter M, Silberg J, Simonoff E. 1993. Whither behavioral genetics? A developmental psychopathological perspective. In Nature, Nurture, and Psychology, ed. R Plomin, GE McClearn, pp. 433-56. Washington, DC: Am. Psychol. Assoc.

Rutter M, Smith D, eds. 1995. Psychosocial Disorders in Young People: Time Trends and Their Causes. Chichester, UK: Wiley

Saudino KJ, Pedersen NL, Lichtenstein P, McClearn GE, Plomin R. 1997. Can personality explain genetic influences on life events? J. Pers. Soc. Psychol. 72:196-206

Scarr S, McCartney K. 1983. How people make their own environment: a theory of genotype --> environmental effects. Child Dev. 54:424-35

Sellers TA, Potter JD, Bailey-Wilson JE, Rich SS, Rothschild H, et al. 1992. Lung cancer detection and prevention: evidence from an interaction between smoking and genetic predisposition. Cancer Res. 52:S2694-97

Silberg J, Pickles A, Rutter M, Hewitt J, Simonoff E, et al. 1999. The influence of genetic factors and life stress on depression among adolescent girls. Arch. Gen. Psychiatry 56:225-32

Silberg J, Rutter M, D'Onofrio B, Eaves L. 2001b. Genetic and Environmental Risk Factors in Adolescent Substance Use. Submitted

Silberg J, Rutter M, Neale M, Eaves L. 2001a. Genetic moderation of environmental risk for depression and anxiety in adolescent girls. Br. J. Psychiatry 179:116-21

Silventoinen K, Kaprio J, Lahelma E, Koskenvuo M. 2000. Relative effect of genetic and environmental factors on body height: differences across birth cohorts among Finnish men and women. Am. J. Public Health 90:627-30

Stoolmiller M. 1999. Implications of the restricted range of family environments for estimates of heritability and nonshared environment in behavior-genetic adoption studies. Psychol. Bull. 125:392-409

Suomi SJ. 2000. A biobehavioral perspective on developmental psychopathology: excessive aggression and serotonergic dysfunction in monkeys. In Handbook of Developmental Psychopathology, ed. AJ Sameroff, M Lewis, S Miller, pp. 237-56. New York: Plenum. 2nd ed.

Talmud PJ, Bujac SR, Hall S, Miller GJ, Humphries SE. 2000. Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers. Atherosclerosis 149:75-81

Teasdale GM, Nicoll JAR, Murray G, Fiddes M. 1997. Association of apolipoprotein E polymorphism with outcome after head injury. Lancet 350:1069-71

Thapar A, Harold G, McGuffin P. 1998. Life events and depressive symptoms in childhood--shared genes or shared adversity? A research note. J. Child Psychol. Psychiatry 39:1153-58

Thapar A, McGuffin P. 1996. Genetic influences on life events in childhood. Psychol. Med. 26:813-20

Truett KR, Eaves LJ, Walters EE, Heath AC, Hewitt JK, et al. 1994. A model system for the analysis of family resemblance in extended kinships of twins. Behav. Genet. 24:35-49

Trumbetta SL, Gottesman II. 2000. Endophenotypes for marital status in the NAS-NRC twin registry. In Genetic Influences on Human Fertility and Sexuality: Theoretical and Empirical Contributions from the Biological and Behavioral Sciences, ed. JL Rodgers, DC Rowe, WB Miller, pp. 253-69. Boston: Kluwer Acad.

Turkheimer E, Gottesman II. 1996. Stimulating the dynamics of genes and environment in development. Dev. Psychopathol. 8:667-77

Turkheimer E, Waldron M. 2000. Nonshared environment: theoretical, methodological, and quantitative review. Psychol. Bull. 126:78-108

van den Oord EJCG, Rowe DC. 1998. An examination of genotype-environment interactions for academic achievement in an U.S. national longitudinal survey. Intelligence 25:205-28

Wahlsten D. 1990. Insensitivity of the analysis of variance to heredity-environment interaction. Behav. Brain Sci. 13:109-61

Wahlsten D. 1999. Experimental design and statistical inference. In Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavioral and Neural Sciences), ed. WE Crusio, RT Gerlai, 13:40-57. The Netherlands: Elsevier

Wahlsten D. 2002. Genetics and the development of brain and behavior. In Handbook of Developmental Psychology, ed. J Valsiner, K Connolly. London: Sage. In press

Weatherall D. 1999. From genotype to phenotype: genetics and medical practice in the new millennium. Philos. Trans. R. Soc. London Ser. B 354:1995-2010

Weatherall DJ, Clegg JB. 2001. The Thalassemia Syndromes. Oxford: Blackwell. 4th ed.

Wolf CR, Smith G, Smith RL. 2000. Science, medicine, and the future: pharmacogenetics. Br. Med. J. 320:987-90

Yaffe K, Haan M, Byers A, Tangen C, Kuller L. 2000. Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction. Neurology 54:1949-53