Behavioral Genetics:  Research Article

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Genetic Polymorphism in Panic Disorder

CITATION:  Jong-Min Woo,  Kyung-Sik Yoon,  Bun-Hee Yu.  (2002)  Catecho O-Methyltransferase Genetic Polymorphism In Panic Disorder.  Am J Psychiatry 159.1785-1787.


Objective: The authors examined the distribution of catechol O-methyltransferase (COMT) genotypes in patients with panic disorder as well as the relationship between a COMT polymorphism and the clinical characteristics of these patients. 

Method: Fifty-one patients with panic disorder and 45 healthy comparison subjects were tested for a genetic polymorphism of COMT. Clinical variables were assessed for the patients with panic disorder. 

Results: The frequency of the L/L genotype was significantly higher in the patients with panic disorder than in the healthy subjects (19.6% versus 2.2%). Panic disorder was significantly associated with the L allele and L/L genotype. Patients with panic disorder who had the L/L genotype showed poorer treatment response than those with other genotypes. 

Conclusion: These results suggest that the L/L genotype of the COMT gene may be related to the development and treatment outcome of panic disorder in some patients.


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