Essential Nutrients-Mood:  Research Article

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Treatment of Mood Lability and Explosive Rage with Minerals and Vitamins

CITATION:  Kaplan, B. J., Crawford, S.G., et al.  (2002)  Treatment of Mood Lability and Explosive Rage with Minerals and Vitamins: Two Case Studies in Children Journal of Child and Adolescent Psychopharmacology.  Volume 12, Number 3, 2002 Pp. 205–219.

ABSTRACT:  A micronutrient supplement containing a broad range of dietary minerals and vitamins is being examined for the treatment of mood lability in both adults and children (Kaplan et al. 2001; Popper 2001). To participate, the child simply had to exhibit mood lability, irritability, uncontrollable temper outbursts, or aggression.  During pilot work, two medication-free boys with mood lability and explosive rage were studied in an open-label treatment followed by reversal and retreatment.

One child was an 8-year-old with atypical obsessive-compulsive disorder, and the other was a 12-year-old with pervasive developmental delay. Both boys were monitored using the mood and temper items from the Conners Parent Rating Scale, as well as the Child Behavior Checklist. 

In addition, the boy with atypical obsessive-compulsive disorder was monitored with the child version of the Yale-Brown Obsessive Compulsive Scale. Both boys benefited from the micronutrient supplement when examined in ABAB designs: mood, angry outbursts, and obsessional symptoms improved when initially treated, returned when not taking the supplement, and remitted when the micronutrient supplement was reintroduced. 

Both boys have been followed and are stable on the nutritional supplement for over 2 years. These cases suggest that mood lability and explosive rage can, in some cases, be managed with a mixture of biologically active minerals and vitamins, without using lithium or other traditional psychopharmacologic agents.

TABLE 1  Ingredients of E.M. Power                                                                       

32 Caps
8 Caps
Children's RDA
Vitamin A (as retinyl palmitate) 9,600 IU 2,400 IU 5,000 IU
Vitamin C (as ascorbic acid) 1,000 mg 250 mg 60 mg
Vitamin D (as cholecalciferol) 1,600 IU 400 IU 400 IU
Vitamin E (as d-alpha tocopheryl succinate) 400 IU 100 IU 30 IU
Vitamin B1 (as thiamine mononitrate) 20 mg 5 mg 1.5 mg
Vitamin B2 (as riboflavin) 22 mg 5.5 mg 1.7 mg
Vitamin B3 (as niacinamide) 100 mg 25 mg 20 mg
Vitamin B6 (as pyridoxine hydrochloride) 28 mg 7 mg 2.0 mg
Vitamin B9 (as folic acid) 1,600 mcg 400 mcg 400 mcg
Vitamin B12 (as cyanocobalamin) 1,000 mcg 250 mcg 6.0 mcg
Biotin 100 mcg 25 mcg 10 mcg
Pantothenic acid (as d-calcium pantothenate) 24 mg 6 mg 10 mg
Calcium (as calcium complex,a calcium
     amino acid chelate) 
2,200 mg 550 mg 1 g
Iron (as iron amino acid chelate, iron complexa) 24 mg 6 mg 18 mg
Phosphorous (phosphorous complexa) 1,400 mg 350 mg 1 g
Iodine (from kelp) 300 mcg 75 mcg 150 mcg
Magnesium (as magnesium amino acid chelate, 
     magnesium complexa)
1,000 mg 250 mg 400 mg
Zinc (as zinc amino acid chelate, zinc complexa) 80 mg  20 mg  10–15 mg
Selenium (as selenium amino acid chelate, 
     selenium complexa)
400 mcg 100 mcg None
Copper (as copper amino acid chelate, 
     copper complexa)
12 mg 3 mg 2 mg
Manganese (as manganese amino acid chelate, 
     manganese complexa)
16 mg 4 mg None
Chromium (as chromium amino acid chelate, 
     chromium complexa)
1,000 mcg 250 mcg None
Molybdenum (as molybdenum amino acid chelate,
     molybdenum complexa)
264 mcg 66 mcg None
Potassium (as potassium complexa) 400 mg 100 mg None

Note: Treatment began with 32 capsules/day; maintenance dose was 8 capsules/day.

There is currently a proprietary blend, for which daily values are not established: dl-phenylalanine, glutamine (as l-glutamine), citrus bioflavonoids (from peel), grape seed (Vitis vinitera), choline (as choline bitartrate), inositol, Ginkgo biloba (from leaf), methionine (as l-methionine), germanium (as Germanium sesquioxide), boron (as boron amino acid chelate), vanadium (as vanadium amino acid chelate, vanadium complexa), and nickel (as nickel amino acid chelate, nickel complexa). Other ingredients include gelatin, magnesium stearate, microcrystalline cellulose, and silicon dioxide. Manufactured for The Synergy Group of Canada, by Evince International, Farmington, Utah. RDA = recommended daily allowance.

aSaccharide complex.


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