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Omega 3 Fatty Acids in Bipolar Disorder

CITATION: Stoll, A.L., Severus, W.E., et al.  (1999) Omega 3 Fatty Acids in Bipolar Disorder:  A Preliminary Double-blind, Placebo-Controlled Trial.  Arch Gen Psychiatry. 1999;56:407-412

ABSTRACT: 


Background: Omega 3 Fatty acids may inhibit neuronal signal transduction pathways in a manner similar to that of lithium carbonate and valproate, 2 effective treatments for bipolar disorder. The present study was performed to examine whether v3 fatty acids also exhibit mood-stabilizing properties in bipolar disorder.

Methods: A 4-month, double-blind, placebocontrolled study, comparing omega 3 fatty acids (9.6 g/d) vs placebo (olive oil), in addition to usual treatment, in 30 patients with bipolar disorder.

Results: A Kaplan-Meier survival analysis of the cohort found that the omega 3 fatty acid patient group had a significantly longer period of remission than the placebo group (P = .002; Mantel-Cox). In addition, for nearly every other outcome measure, the omega 3 fatty acid group performed better than the placebo
group.

Conclusion: Omega 3 Fatty acids were well tolerated and improved the short-term course of illness in this preliminary study of patients with bipolar disorder.

References

1. Goodwin FK, Jamison KR. Manic Depressive Illness. Oxford, England: Oxford
University Press; 1990.

2. Gitlin MJ, Swendsen J, Heller TL, Hammen C. Relapse and impairment in bipolar
disorder. Am J Psychiatry. 1995;152:1635-1640.

3. Stoll AL, Severus E. Mood stabilizers: shared mechanisms of action at postsynaptic
signal transduction and kindling processes.Harvard Rev Psychiatry. 1996;
4:77-89.

4. Berridge MJ, Downes CP, Hanley MR. Lithium amplifies agonist-dependent phosphatidylinositol
responses in brain and salivary glands. Biochem J. 1982;206:
587-595.

5. Chen G, Manji HK, Hawver DB, Wright CB, Potter WZ. Chronic sodium valproate
selectively decreases protein kinase C a and e in vitro. J Neurochem. 1994;63:
2361-2364.

6. Manji HK, Bersudsky Y, Chen G, Belmaker RH, Potter WZ. Modulation of protein
kinase C isozymes and substrates by lithium: the role of myo-inositol. Neuropsychopharmacology.
1996;15:370-381.

7. Stensby ME. Nutritional properties of fish oils. World Rev Nutr Diet. 1969;11:
46-105.

8. Sperling RI, Benincaso AI, Knoell CT, Larkin JK, Austen KF, Robinson DR. Dietary
omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and
chemotaxis in neutrophils. J Clin Invest. 1993;91:651-660.

9. Tappia PS, Ladha S, Clark DC, Grimble RF. The influence of membrane fluidity,
TNF receptor binding, cAMP production and GTPase activity on macrophage cytokine
production in rats fed a variety of fat diets. Mol Cell Biochem. 1997;166:
135-143.

10. American Psychiatric Association. Diagnostic and Statistical Manual of Mental
Disorders, Fourth Edition. Washington, DC: American Psychiatric Association;
1994.

11. Spitzer R. Structured Clinical Interview for DSM-IV. Washington, DC: American
Psychiatric Association; 1994.

12. Dunner DL, Fieve RR. Clinical factors in lithium carbonate prophylaxis failure.
Arch Gen Psychiatry. 1974;30:229-233.

13. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability,
validity and sensitivity. Br J Psychiatry. 1978;133:429-435.

14. Williams JB. A structured interview guide for the Hamilton Depression Rating
Scale. Arch Gen Psychiatry. 1988;45:742-747.

15. Guy N. ECDEU Assessment Manual for Psychopharmacology. Washington, DC:  US Dept of Health, Education, and Welfare; 1976.

16. Medini L, Colli S, Mosconi C, Tremoli E, Galli C. Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. Biochem Pharmacol. 1990;39:129-133.

17. Barton PG, Gunstone FD. Hydrocarbon chain packing and molecular motion in
phospholipid bilayers formed from unsaturated lecithins. J Biol Chem. 1975;
250:4470-4476.

18. Bourre JM, Bonneil M, Clement M, Dumont O, Durand G, Lafont H, Nalbone G,
Piciotti M. Function of dietary polyunsaturated fatty acids in the nervous system.
Prostaglandins Leukot Essent Fatty Acids. 1993;48:5-15.