INGESTED INTOLERANCES and TOXINS
Ingested Intolerances and Toxins-Physical: Research Article
Executive Summary: Body Burden — The Pollution in Newborns
Environmental Working Group, July
Summary: In the month leading up to a baby's birth, the umbilical cord pulses with the equivalent of at least 300 quarts of blood each day, pumped back and forth from the nutrient- and oxygen-rich placenta to the rapidly growing child cradled in a sac of amniotic fluid. This cord is a lifeline between mother and baby, bearing nutrients that sustain life and propel growth.
Not long ago scientists thought that the placenta shielded cord blood — and the developing baby — from most chemicals and pollutants in the environment. But now we know that at this critical time when organs, vessels, membranes and systems are knit together from single cells to finished form in a span of weeks, the umbilical cord carries not only the building blocks of life, but also a steady stream of industrial chemicals, pollutants and pesticides that cross the placenta as readily as residues from cigarettes and alcohol. This is the human "body burden" — the pollution in people that permeates everyone in the world, including babies in the womb.
In a study spearheaded by the Environmental Working Group (EWG) in collaboration with Commonweal, researchers at two major laboratories found an average of 200 industrial chemicals and pollutants in umbilical cord blood from 10 babies born in August and September of 2004 in U.S. hospitals. Tests revealed a total of 287 chemicals in the group. The umbilical cord blood of these 10 children, collected by Red Cross after the cord was cut, harbored pesticides, consumer product ingredients, and wastes from burning coal, gasoline, and garbage.
This study represents the first reported cord blood tests for 261 of the targeted chemicals and the first reported detections in cord blood for 209 compounds. Among them are eight perfluorochemicals used as stain and oil repellants in fast food packaging, clothes and textiles — including the Teflon chemical PFOA, recently characterized as a likely human carcinogen by the EPA's Science Advisory Board — dozens of widely used brominated flame retardants and their toxic by-products; and numerous pesticides. Of the 287 chemicals we detected in umbilical cord blood, we know that 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development in animal tests. The dangers of pre- or post-natal exposure to this complex mixture of carcinogens, developmental toxins and neurotoxins have never been studied.
Chemicals and pollutants detected
in human umbilical cord blood
Source: Chemical analyses of 10 umbilical cord blood samples were conducted by AXYS Analytical Services (Sydney, BC) and Flett Research Ltd. (Winnipeg, MB).
3M. 2000. Biodegradation study of PFOS. AR226-0057. Washington, DC: U.S. Environmental Protection Agency.
3M. 2001a. Screening Studies in the Aqueous Photolytic Degradation of Perfluorooctanoic Acid (PFOA). AR226-1030 Photolysis E00-2192. Washington, DC: U.S. Environmental Protection Agency.
3M. 2001b. Hydrolysis Reactions of Perfluorooctanoic Acid (PFOA). AR2261030a090. Washington, DC: U.S. Environmental Protection Agency.
ACS (American Cancer Society). 2001. Cancer Facts & Figures 2001. Available online at http://www.cancer.org/docroot/STT/stt_0_2001.asp?sitearea=STT&level=1.
ACS (American Cancer Society). 2004. Cancer Facts & Figures 2004. Available online at http://www.cancer.org/docroot/STT/stt_0_2004.asp?sitearea=STT&level=1.
Ananth CV, Misra DP, Demissie K, Smulian JC. 2001. Rates of preterm delivery among Black women and White women in the United States over two decades: an age-period-cohort analysis. Am J Epidemiol. 154:657-65.
Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 2005 Jun 3;308(5727):1466-9.
ATSDR (Agency for Toxic Substances and Disease Registry). 1994. Toxicological profile for chlorodibenzofurans.
ATSDR (Agency for Toxic Substances and Disease Registry). 1995. Toxicological profile for mirex and chlordecone.
ATSDR (Agency for Toxic Substances and Disease Registry). 1995. Toxicological profile for polycyclic aromatic hydrocarbons.
ATSDR (Agency for Toxic Substances and Disease Registry). 1998. Toxicological profile for dibenzo-p-dioxins.
ATSDR (Agency for Toxic Substances and Disease Registry). 2000a. Toxicological profile for polychlorinated biphenyls (PCBs).
ATSDR (Agency for Toxic Substances and Disease Registry). 2004. Guidance manual for the assessment of joint toxic actions of chemical mixtures. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Auer, C. 2000. Phaseout of PFOS. Internal memorandum from Charles Auer, Environmental Protection Agency (EPA). EPA Office of Pollution Prevention and Toxics Docket Number AR226-0629. May 16 2000.
Barker DJP. 1995. Fetal origins of coronary heart disease. BMJ 1995;311:171-174.
Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J Neurosci. 2005 Jan 26;25(4):823-9.
Belles-Isles M, Ayotte P, Dewailly E, Weber J-P, Roy R. 2002. Cord Blood Lymphocyte functions in newborns from a remote maritime population exposed to organochlorines and methylmercury Journal of Toxicology and Environmental Health, Part A, 65:165-182.
Bergstrom R, Adami HO, Mohner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Akre O, Hakulinen T. 1996. Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J Natl Cancer Inst 88:727-33.
Bilrha H, Roy R, Moreau B, Belles-Isles M, Dewailly E, Ayotte P. 2003. In Vitro Activation of Cord Blood Mononuclear Cells and Cytokine Production in a Remote Coastal Population Exposed to Organochlorines and Methyl Mercury. Environmental Health Perspectives. 111: 1952-1957.
Birnbaum LS, Staskal DF, Diliberto JJ. 2003. Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). Environ Int. Sep;29(6):855-60.
Bocskay KA, Tang D, Orjuela MA, Liu X, Warburton DP, Perera FP. 2005. Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons. Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):506-11.
Branum AM, Schoendorf KC. 2002. Changing patterns of low birthweight and preterm birth in the United States, 1981-98. Paediatr Perinat Epidemiol. 2002 Jan;16(1):8-15.
BSEF (Bromine Science and Environmental Forum). 2002. An introduction to brominated flame retardants. Brussels, Belgium, 1-28.
Burris JM, Lundberg JK, Olsen GW, Simpson D, Mandel JH. 2002. Interim report: Determination of serum half-lives of several fluorochemicals. AR226-1086. Washington, DC: U.S. Environmental Protection.
Byrd RS. 2002. The Epidemiology of Autism in California: A Comprehensive Pilot Study. Available online at http://mindinstitute.ucdmc.ucdavis.edu/news/study_final.pdf.
Carrington CD, Montwill B, Bolger PM. 2004. An intervention analysis for the reduction of exposure to methylmercury from the consumption of seafood by women of child-bearing age. Regul Toxicol Pharmacol. 2004 Dec;40(3):272-80.
CDC (Centers for Disease Control and Prevention). 1995. Asthma — United States, 1982-1993. MMWR Morb Mortal Wkly Rep. 43:952-955.
CDC (Centers for Disease Control and Prevention). 2003. Second national report on human exposure to environmental chemicals. NCEH Pub. No. 03-0022. Available at: http://www.cdc.gov/exposurereport/2nd/pdf/secondner.pdf.
CDC (Centers for Disease Control and Prevention). 2004. Chronic Disease Overview. Available online at http://www.cdc.gov/nccdphp/overview.htm.
CDC (Centers for Disease Control and Prevention). 2005. Chemicals for inclusion in the third national exposure report. Available at: http://www.cdc.gov/exposurereport/.
Chakrabarti S, Fombonne E. 2001. Pervasive developmental disorders in preschool children. JAMA 285:3093-9.
Checkoway H, Nelson LM. 1999. Epidemiologic approaches to the study of Parkinson's disease etiology. Epidemiology 10:327-36.
Cook JD, Davis BJ, Cai SL, Barrett JC, Conti CJ, Walker CL. 2005. Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8644-9. Epub 2005 Jun 3.
Cooper GS, Klebanoff MA, Promislow J, Brock JW, Longnecker MP. 2005.Polychlorinated biphenyls and menstrual cycle characteristics. Epidemiology. 2005 Mar;16(2):191-200.
de Rosa CT, El-Masri HA, Pohl H, Cibulas W, Mumtaz MM. 2004. Implications of chemical mixtures in public health practice. J Toxicol Environ Health B Crit Rev. 7, 339-50.
de Wit, C. 2002. An overview of brominated flame retardants in the environment. Chemosphere. (46):583-624.
DHHS (U.S. Department of Health and Human Services). 2004. The National Children's Study. Background information available online at http://www.nationalchildrensstudy.gov/.
Dinglasan MJ, Ye Y, Edwards EA, Mabury SA. 2004. Fluorotelomer alcohol biodegradation yields poly- and perfluorinated acids. Environ Sci Technol. 38: 2857-2864.
Dunson DB, Baird DD, Colombo B. 2004. Increased infertility with age in men and women. Obstet Gynecol. 103:51-56.
Ellis DA, Martin JW, De Silva AO, Mabury SA, Hurley MD, Sulbaek Andersen MP, Wallington TJ. 2004. Degradation of fluorotelomer alcohols: a likely atmospheric source of perfluorinated carboxylic acids. Environ Sci Technol. 38: 3316-3321.
Engel LS, Checkoway H, Keifer MC, Seixas NS, Longstreth WT, Jr., Scott KC, Hudnell K, Anger WK, Camicioli R. 2001. Parkinsonism and occupational exposure to pesticides. Occup Environ Med 58:582-9.
EPA (U.S. Environmental Protection Agency). 1983. Category of chemical substances known as chlorinated naphthalenes: proposed determination of significant new uses. Federal register, 48(89):20668-20679.
EPA (U.S. Environmental Protection Agency). 1996. PCBs: Cancer Dose-Response Assessment and Application to Environmental Mixtures. EPA/600/P-96/001F.
EPA (U.S. Environmental Protection Agency). 1997. Chemistry assistance manual for premanufacture notification submitters. EPA 744-R-97-003. Available online at http://www.epa.gov/oppt/newchems/chem-pmn/.
EPA (U.S. Environmental Protection Agency). 2000a. Dioxin Reassassment. Online: http://cfpub.epa.gov/ncea/cfm/dioxreass.cfm?ActType = default.
EPA (U.S. Environmental Protection Agency). 2000b. EPA and 3M Announce Phase Out of PFOS. News Release. May 16 2000. Available online at http://yosemite.epa.gov/opa/admpress.nsf/0/33aa946e6cb11f35852568e1005246b4?OpenDocument.
EPA (U.S. Environmental Protection Agency). 2002a. Pesticide industry sales and usage 1994 and 1995 market estimates. Available online at http://www.epa.gov/oppbead1/pestsales/95pestsales/.
EPA (U.S. Environmental Protection Agency). 2002b. Revised draft hazard assessment of perfluorooctanoic acid and its salts. US EPA Office of Pollution Prevention and Toxics. 4 November, 2002. AR226-1136. Washington, DC: U.S. Environmental Protection Agency.
EPA (U.S. Environmental Protection Agency). 2003a. America's children and the environment. Measures of contaminants, body burdens, and illnesses. Available online at http://www.epa.gov/envirohealth/children.
EPA (U.S. Environmental Protection Agency). 2003b. Dioxin Reassassment. Online: http://cfpub.epa.gov/ncea/cfm/dioxreass.cfm?ActType = default
EPA (U.S. Environmental Protection Agency). 2003c. Preliminary risk assessment of the developmental toxicity associated with exposure to perfluorooctanoic acid and its salts. 10 April 2003. OPPT-2003-0012-0002. Washington, DC: U.S. Environmental Protection Agency Office of Pollution Prevention and Toxics.
EPA (U.S. Environmental Protection Agency). 2003d. EPA intensifies scientific investigation of a chemical processing aid. Environmental News. 14 April 2003. Washington, DC: U.S. Environmental Protection Agency Office of Public Affairs.
EPA (U.S. Environmental Protection Agency). 2004a. NAS Review Draft of EPA's Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds.
EPA (U.S. Environmental Protection Agency). 2004b. USEPA complaint against E.I. du Pont de Nemours and Co. Docket # TSCA-HQ-2004-0016, RCRA-HQ-2004-0016, and TSCA-HQ-2005-5001.
EPA (U.S. Environmental Protection Agency). 2004c. Request for a Motion for Temporary Stay of Proceeding. Exhibit 7. Docket # TSCA-HQ-2004-0016, TSCA-HQ-2005-5001.
EPA (U.S. Environmental Protection Agency). 2005a. Supplemental guidance for assessing susceptibility from early-life exposures to carcinogens. EPA Risk Assessment Forum. EPA/630/R-03/003F. March 2005. [Final version of 2003 Draft].
EPA (U.S. Environmental Protection Agency). 2005b. Fact sheets on new active ingredients. Available online at http://www.epa.gov/opprd001/factsheets/.
EPA (U.S. Environmental Protection Agency). 2005c. What is the TSCA Chemical Substance Inventory? EPA Office of Prevention, Pesticides and Toxic Substances. Available online at http://www.epa.gov/opptintr/newchems/invntory.htm. Accessed May 15, 2005.
EPA (U.S. Environmental Protection Agency). 2005d. Draft Risk Assessment of the potential human health effects associated with exposure to perfluorooctanoic acid and its salts. January 4, 2005. (Released January 12, 2005). Available online at http://www.epa.gov/oppt/pfoa.
Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ. 1999. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. Bmj 318:427-31.
Eriksson J, Forsen T, Tuomilehto J, Osmond C, Barker D. 2000a. Fetal and childhood growth and hypertension in adult life. Hypertension 36:790-4.
Eriksson JG, Forsen T, Tuomilehto J, Osmond C, Barker DJ. 2000b. Early growth, adult income, and risk of stroke. Stroke 31:869-74.
Eriksson JG, Forsen T, Tuomilehto J, Jaddoe VW, Osmond C, Barker DJ. 2002. Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals. Diabetologia 45:342-8.
Eriksson JG, Forsen TJ. 2002. Childhood growth and coronary heart disease in later life. Ann Med 34:157-61.
EWG (Environmental Working Group). 2003. Mothers Milk: Record levels of toxic fire retardants found in American mothers' breast milk. Washington, DC. Available online at http://www.ewg.org/reports/mothersmilk/
EWG (Environmental Working Group). 2003. Body Burden: The Pollution in People. Washington, DC. Available online at http://www.ewg.org/reports/bodyburden/
Faroon O, Jones D, de Rosa C. 2001. Effects of polychlorinated biphenyls on the nervous system. Toxicol Ind Health. 2001 Sep;16(7-8):305-33. Review.
FDA (U.S. Food and Drug Administration). 2000. Cosmetics Compliance Program. Domestic Cosmetics Program. July 31, 2000. Available online at http://www.cfsan.fda.gov/~comm/cp29001.html.
FDA (U.S. Food and Drug Administration). 2004. Backgrounder for the 2004 FDA/EPA Consumer Advisory: What You Need to Know About Mercury in Fish and Shellfish. Available online at http://www.fda.gov/oc/opacom/hottopics/mercury/backgrounder.html.
FDA (U.S. Food and Drug Administration). 2005. EAFUS: A Food Additive Database. (Everything Added to Food in the U.S.). FDA Center for Food Safety and Applied Nutrition. Available online at http://www.cfsan.fda.gov/~dms/eafus.html.
Forsen T, Eriksson J, Tuomilehto J, Reunanen A, Osmond C, Barker D. 2000. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med 133:176-82.
Furlong ET, Carter DS, Hites RA. 1988. Organic contaminants in sediments from the Trenton Channel of the Detroit River, Michigan. Journal of Great Lakes research. 14:489-501.
Godfrey KM, Barker DJ. 2001.
Fetal programming and adult health. Public Health Nutr 4:611-24.
Greene, Alan. 2004. From First Kicks to First Steps: Nurturing Your Baby's Development from Pregnancy Through the First Year of Life. McGraw-Hill Companies. New York.
Hack M, Flannery DJ, Schluchter M, Cartar L, Borawski E, Klein N. 2002. Outcomes in young adulthood for very-low-birth-weight infants. N Engl J Med. 2002 Jan 17;346(3):149-57.
Hagen, Donald F.; Belisle, John; Johnson, James D.; and Venkateswarlu, P. 1981. Characterization of Fluorinated Metabolites by a Gas Chromatographic- Helium Microwave Plasma Detector; The Biotransformation of 1H, 1H, 2H, 2H-Perfluorodecanol to Perfluorooctanoate. Analytical Biochemistry. 118, 336-343.
Hale. 2001. Polybrominated Diphenyl Ether Flame Retardants in Virginia Freshwater Fishes (USA). Environmental Science and Technology. 35(23):4585-4591.
Hales CN, Barker DJ. 2001. The thrifty phenotype hypothesis. Br Med Bull 60:5-20.
Hales CN, Barker DJP, Clark PMS, Cox LJ, Fall C, Winter PD. 1991. Fetal and infant growth and impaired glucose tolerance at age 64 years. BMJ 303:1019-1022.
Hales CN, Ozanne SE. 2003. For debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia. 2003 Jul;46(7):1013-9. Epub 2003 Jun 21. Review.
Hardell L, van Bavel B, Lindstrom G, Carlberg M, Dreifaldt AC, Wijkstršm H, Starkhammar H, Eriksson M, Hallquist A, Kolmert T. in press. Increased Concentrations of Polychlorinated Biphenyls, Hexachlorobenzene and Chlordanes in Mothers to Men with Testicular Cancer. Environ Health Perspect [Online 19 December 2002].
Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, Hasemeier CM. 1997. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 99:505-12.
Hooper K, McDonald TA. 2000. The PBDEs: an emerging environmental challenge and another reason for breast-milk monitoring programs. Environ Health Perspect. May;108(5):387-92.
Hosie S, Loff S, Witt K, Niessen K, Waag KL. 2000. Is there a correlation between organochlorine compounds and undescended testes? Eur J Pediatr Surg 10:304-9.
Jacobson JL, Jacobson SW. 1996. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 335:783-9.
Jahnke GD, Iannucci AR, Scialli
AR, Shelby MD. 2005. Center for the evaluation of risks to human
reproduction--the first five years. Birth Defects Res B Dev Reprod
Toxicol. 2005 Feb;74(1):1-8. Review.
Kissa E. 2001. Fluorinated Surfactants and Repellents. Marcel Dekker, Inc., New York.
Kuehl DW, Durhan E, Butterworth BC, Linn D. 1984. Tetrachloro-9H-carbazole, a previously unrecognized contaminant in sediments of the Buffalo River. Journal of Great Lakes research, 10:210-214.
Lagueux J, Pereg D, Ayotte P, Dewailly E, Poirer GG. 1999. Cytochrome P450 CYP1A1 Enzyme Activity and DNA Adducts in Placenta of Women Environmentally Exposed to Organochlorines. Environmental Research Section A 80:369-382.
Longnecker MP, Klebanoff MA, Zhou H, Brock JW. 2001. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet 358:110-4.
Makri A, Goveia M, Balbus J, Parkin R. 2004. Children's susceptibility to chemicals: a review by developmental stage. J Toxicol Environ Health B Crit Rev. 2004 Nov-Dec;7(6):417-35. Review.
Martin JW, Smithwick MM, Braune BM, Hoekstra PF, Muir DC, Mabury SA. 2004. Identification of long-chain perfluorinated acids in biota from the Canadian Arctic. Environ Sci Technol. 38:373-380.
Mazdai A, Dodder NG, Abernathy MP, Hites RA, Bigsby RM. 2003. Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ Health Perspect. 2003 Jul;111(9):1249-52.
McKiernan JM, Goluboff ET, Liberson GL, Golden R, Fisch H. 1999. Rising risk of testicular cancer by birth cohort in the United States from 1973 to 1995. J Urol 162:361-3.
Mocarelli P, Brambilla P, Gerthoux PM, Patterson DG, Jr., Needham LL. 1996. Change in sex ratio with exposure to dioxin. Lancet 348:409.
Mocarelli P, Gerthoux PM, Ferrari E, Patterson DG, Jr., Kieszak SM, Brambilla P, Vincoli N, Signorini S, Tramacere P, Carreri V, Sampson EJ, Turner WE, Needham LL. 2000. Paternal concentrations of dioxin and sex ratio of offspring. Lancet 355:1858-63.
NAS (National Academies of Science). 1972. Degradation of Synthetic Organic Molecules in the Biosphere. Washington, DC.
NAS (National Academy of Sciences). 1993. Pesticides in the Diets of Infants and Children. National Academy Press. Washington, DC.
NAS (National Academy of Sciences). 2000a. Scientific Frontiers in Developmental Toxicology and Risk Assessment. Committee on Developmental Toxicology. Washington, DC: National Academies Press.
NAS (National Academy of Sciences). 2000b. Toxicological Effects of Methylmercury. National Research Council. National Academy Press, Washington, DC.
NCI (National Cancer Institute). 1996. SEER Cancer Statistics Review. 1973-1996. Available online at http://www.seer.ims.nci.nih.gov/Publications/CSR1973_1996/.
NCI (National Cancer Institute). 1997. SEER Cancer Statistics Review. 1973-1997. Available online at http://www.seer.ims.nci.nih.gov/Publications/CSR1973_1997/.
NCI (National Cancer Institute). 2005. Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER*Stat Database: Nov 2004 Sub (1973-2002), NCI, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005.
NIEHS (National Institute for Environmental Health Sciences). 2001. Toxicological Summary for Selected Polybrominated Diphenyl Ethers. Submitted by Bonnie Carson, Integrated Laboratory Systems, Research Triangle Park, North Carolina. March, 2001.
Noren K, Meironyte D. 2000. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere. 2000 May-Jun;40(9-11):1111-23.
NTP (National Toxicology Program). 2004. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
OECD (Organisation for Economic Co-operation and Development). 2002. Hazard assessment of perfluorooctane sulfonate (PFOS) and its salts. ENV/JM/RD(2002)17/FINAL.
Olsen GW, Burris JM, Lundberg JK, Hansen KJ, Mandel JH, Zobel LR. 2002a. Final Report: Identification of fluorochemicals in human sera. III. Pediatric participants in a group A streptococci clinical trial investigation. AR2261085. Washington, DC: U.S. Environmental Protection Agency.
Olsen GW, Burris JM, Lundberg JK, Hansen KJ, Mandel JH, Zobel LR. 2002b. Final Report: Identification of fluorochemicals in human sera. I. American Red Cross Adult Blood Donors. AR226-1083. Washington, DC: U.S. Environmental Protection Agency.
Olsen GW, Burris JM, Lundberg JK, Hansen KJ, Mandel JH, Zobel LR. 2002c. Final Report: Identification of fluorochemicals in human sera. II. Elderly participants of the adult changes in thought study, Seattle, WA. AR2261084. Washington, DC: U.S. Environmental Protection Agency.
Ong KK, Dunger DB. 2002. Perinatal growth failure: the road to obesity, insulin resistance and cardiovascular disease in adults. Best Pract Res Clin Endocrinol Metab 16:191-207.
Paulozzi LJ, Erickson JD, Jackson RJ. 1997. Hypospadias trends in two US surveillance systems. Pediatrics 100:831-4.
Paulozzi LJ. 1999. International trends in rates of hypospadias and cryptorchidism. Environ Health Perspect. 1999 Apr;107(4):297-302.
Pirkle JL, Brody DJ, Gunter EW, Kramer RA, Paschal DC, Flegal KM, Matte TD. 1994. The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES). JAMA 272, 284-291.
Prentice AM, Moore SE. 2005. Early programming of adult diseases in resource poor countries. Arch Dis Child. 90:429-432.
Rhainds M, Levallois P, Dewailly E, Pierre A. 1999. Lead, Mercury, and Organochlorine Compound Levels in Cord Blood in Quebec, Canada. Archives of Environmental Health. 54:40-47.
Robison LL, Buckley JD, Bunin G. 1995. Assessment of environmental and genetic factors in the etiology of childhood cancers: the Childrens Cancer Group epidemiology program. Environ Health Perspect 111:201-206.
Robison LM, Sclar DA, Skaer TL, Galin RS. 1999. National trends in the prevalence of attention-deficit/hyperactivity disorder and the prescribing of methylphenidate among school-age children: 1990-1995. Clin Pediatr (Phila) 38:209-17.
Robison LM, Skaer TL, Sclar DA, Galin RS. 2002. Is attention deficit hyperactivity disorder increasing among girls in the US? Trends in diagnosis and the prescribing of stimulants. CNS Drugs 16:129-37.
Salonen, JT, K Seppanen, et al. 1995. Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in eastern Finnish men. Circulation. 91(3): 645-655.
Schade G, Heinzow B. 1998. Organochlorine pesticides and polychlorinated biphenyls in human milk of mothers living in northern Germany: current extent of contamination, time trend from 1986 to 1997 and factors that influence the levels of contamination. Sci Total Environ 215(1-2):31-39.
Schecter A, Kassis I, Papke O. 1998. Partitioning of dioxins, dibenzofurans, and coplanar PCBS in blood, milk, adipose tissue, placenta and cord blood from five American women. Chemosphere. 1998 Oct-Nov;37(9-12):1817-23.
Schechter CB. 1999. Re: Brain and other central nervous system cancers: recent trends in incidence and mortality. J Natl Cancer Inst. 91:2050-2051.
Selevan SG, Kimmel CA, Mendola P. 2000. Identifying critical windows of exposure for children's health. Environ Health Perspect. 2000 Jun;108 Suppl 3:451-5.
Sexton K, Needham LL, Pirkle JL. 2004. Measuring chemicals in human tissues is the "gold standard" for assessing people’s exposure to pollution. American Scientist. 92, 38-45.
Sorensen N, Murata K, Budtz-Jorgensen E, Weihe P, Grandjean P. 1999. Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age. Epidemiology. 10:370-375.
Srivastava VK, Chauhan SS, Srivastava PK, Kumar V and Misra UK. 1986. Fetal translocation and metabolism of PAH obtained from coal fly ash given intratracheally to pregnant rats. J Toxicol Environ Health. 18, 459-469.
Stettler N, Bovet P, Shamlaye H, Zemel BS, Stallings VA, Paccaud F. 2002. Prevalence and risk factors for overweight and obesity in children from Seychelles, a country in rapid transition: the importance of early growth. Int J Obes Relat Metab Disord 26:214-9.
Stewart P, Darvill T, Lonky E, Reihman J, Pagano J, Brush B. 1999. Assessment of prenatal exposure to PCBs from maternal consumption of Great Lakes fish: An analysis of PCB pattern and concentration. Environmental Research Section A 80, S87-S96.
Stewart P, Reihman J, Lonky E, Darvill T, Pagano J. 2000. Prenatal PCB exposure and neonatal behavioral assessment scale (NBAS) performance. Neurotoxicology and Teratology 22:21-29.
Stock NL, Lau FK, Ellis DA, Martin JW, Muir DC, Mabury SA. 2004. Polyfluorinated telomer alcohols and sulfonamides in the North American troposphere. Environ Sci Technol 38: 991-996.
Swan SH, Elkin EP, Fenster L. 2000. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect 108:961-6.
Swan SH, Brazil C, Drobnis EZ, Liu F, Kruse RL, Hatch M, Redmon JB, Wang C, Overstreet JW; Study For Future Families Research Group. 2003. Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect. 2003 Apr;111(4):414-20.
Syme MR, Paxton JW, Keelan JA. 2004. Drug transfer and metabolism by the human placenta. Clin Pharmacokinet 2004;43(8):487-514.
Tango T, Fujita T, Tanihata T, Minowa M, Doi Y, Kato N, Kunikane S, Uchiyama I, Tanaka M, Uehata T. 2004. Risk of adverse reproductive outcomes associated with proximity to municipal solid waste incinerators with high dioxin emission levels in Japan. J Epidemiol. 2004 May;14(3):83-93.
ten Tusscher GW, Koppe JG. 2004. Perinatal dioxin exposure and later effects — a review. Chemosphere. 54:1329-1336.
Thompson C, Syddall H, Rodin I, Somond C, Barker DJ. 2001. Birth weight and the risk of depressive disorder in late life. Br J Psychiatry. 2001 Nov;179-450-5.
Thornton JW, M McCally, J Houlihan. 2002. Biomonitoring of industrial pollutants: Health and policy implications of the chemical body burden. Public Health Reports. Vol 117, 315-323.
Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ, Jr., Jegou B, Jensen TK, Jouannet P, Keiding N, Leffers H, McLachlan JA, Meyer O, Muller J, Rajpert-De Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek NE. 1996. Male reproductive health and environmental xenoestrogens. Environ Health Perspect 104 Suppl 4:741-803.
Trasande L, Landrigan PJ. 2004. The National Children's Study: a critical national investment. Environ Health Perspect. 2004 Oct;112(14):A789-90.
Van Loveren H, Vos J, Putman E, Piersma A. 2003. Immunotoxicological consequences of perinatal chemical exposures: a plea for inclusion of immune parameters in reproduction studies. Toxicology. 2003 Apr 1;185(3):185-91. Review.
Viberg H, Fredriksson A, Jakobsson E, Orn U, Eriksson P. 2003. Neurobehavioural Derangements in Adult Mice Receiving Decabrominated Diphenyl Ether (PBDE 209) During a Defined Period of Neonatal Brain Development. Toxicol Sci. 76:112-20.
WA DOH (Washington State Department of Health). 2005. PBDEs: What they are and what you can do. Available online at http://www.doh.wa.gov/ehp/oehas/pbde/pbdeuse.htm.
Wahlbeck K, Forsen T, Osmond C, Barker DJ, Eriksson JG. 2001. Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood. Arch Gen Psychiatry. 2001 Jan;58(1):48-52.
Walker JB, Seddon L, McMullen E, Houseman J, Tofflemire K, Corrivear A, Weber J-P, Mills C, Smith S, Van Oostdam J. 2003. Organochlorine levels in maternal and umbilical cord blood plasma in Arctic Canada The Science of the Total Environment 302:27-52.
Weidner IS, Moller H, Jensen TK, Skakkebaek NE. 1998. Cryptorchidism and hypospadias in sons of gardeners and farmers. Environ Health Perspect 106:793-6.
WHO (World Health Organization). 1998. Polybrominated dibenzo-p-dioxins and dibenzofurans. Environ Health Criteria 205.
WHO (World Health Organization). 2001. Chlorinated naphthalenes. Concise International Chemical Assessment Document 34. Available online at http://www.inchem.org/documents/cicads/cicads/cicad34.htm.
Whyatt RM, Jedrychowski W, Hemminki K, Santella RM, Tsai KY, and Perera FP. 2001. Biomarkers of polycyclic aromatic hydrocarbon-DNA damage and cigarette smoke exposures in paired maternal and newborn blood samples as a measure of differential susceptibility. Cancer Epidemiology, Biomarkers & Prevention. 10, 581-588.
Yang JZ, Agarwal SK, Foster WG. 2000. Subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates the pathophysiology of endometriosis in the cynomolgus monkey. Toxicol Sci 56:374-81.
Yeargin-Allsopp M, Rice C, Karapurkar T, Doernberg N, Boyle C, Murphy C. 2003. Prevalence of Autism in a US Metropolitan Area. JAMA. 289:49-55.
Zito JM, Safer DJ, dosReis S,
Gardner JF, Boles M, Lynch F. 2000. Trends in the prescribing of
psychotropic medications to preschoolers. JAMA 283:1025-30.