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Neurodegenerative Diseases and Exposure to Pesticides in the Elderly

CITATION:  Baldi, L, Pierre, L, et al.  (2003).  Neurodegenerative Diseases and Exposure to Pesticides in the Elderly.  Am J Epidemiol;157:409–414.

ABSTRACT:  The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.


1. Lilienfeld D, Perl D. Projected neuro-degenerative disease mortality
among minorities in the United States 1900–2010.
Neuroepidemiology 1994;13:179–86.

2. Lilienfeld D, Perl D. Projected neuro-degenerative disease mortality
in the United States 1900–2010. Neuroepidemiology

3. Schulte PA, Burnett CA, Boeninger MF, et al. Neurodegenerative
diseases: occupational occurrence and potential risk factors.
Am J Public Health 1996;86:1281–8.

4. Priyadarshi A, Khuder SA, Schaub EA, et al. A meta-analysis of
Parkinson’s disease and exposure to pesticides. Neurotoxicology

5. Cole D, Carpio F, Julian J, et al. Neurobehavioural outcomes
among farm and nonfarm rural Ecuadorians. Neurotoxicol Teratol

6. Rosenstock L, Keifer M, Daniell WE, et al. Chronic central nervous
system effects of acute organophosphate pesticide intoxication.
Lancet 1991;338:223–7.

7. Stephens R, Spurgeaon A, Calvert IA, et al. Neuropsychological
effects of long-term exposure to organophosphates in sheep
dip. Lancet 1995;345:1135–9.

8. Steenland K, Cedillo L, Tucker J, et al. Thyroid hormones and
cytogenetic outcomes in backpack sprayers using ethylenebis(
dithiocarbamate) (EBDC) fungicides in Mexico. Environ
Health Perspect 1997;105:1126–30.

9. Fabrigoule C, Rouch I, Taberly A, et al. Cognitive process in
preclinical phase of dementia. Brain 1998;121:135–41.

10. Baldi I, Filleul L, Mohammed-Brahim B, et al. Neuropsychologic
effects of long-term exposure to pesticides: results from
the French Phytoner Study. Environ Health Perspect 2001;109:

11. Gauthier E, Fortier I, Courchesne F, et al. Environmental pesticide
exposure as a risk factor for Alzheimer’s disease: a casecontrol
study. Environ Res 2001;86:37–45.

12. The Canadian Study of Health and Aging: risk factors for
Alzheimer’s disease in Canada. Neurology 1994;44:2073–80.

13. Dartigues JF, Gagnon M, Barberger-Gateau P, et al. The
PAQUID epidemiological program on brain ageing.
Neuroepidemiology 1992;11(suppl 1):14–18.

14. Institut National de la Statistique et des Etudes Economiques.
Nomenclature des professions et catégories socio-professionnelles.
Paris, France: Institut National de la Statistique et des
Etudes Economiques, 1994.

15. Folstein M, Folstein S, McHugh P. “Mini-Mental State”: a
practical method for grading the cognitive state of patients for
the clinician. J Psychiatr Res 1975;12:189–98.

16. War Department, Adjudant General’s Office. Army Individual
Test Battery: manual of directions and scoring. Washington,
DC: War Department, Adjudant General’s Office, 1944.

17. McCann SJ, LeCouteur DG, Green AC, et al. The epidemiology
of Parkinson’s disease in an Australian population.
Neuroepidemiology 1998;17:310–17.

18. Wade JP, Mirsen TR, Hachinski VC, et al. The clinical diagnosis
of Alzheimer’s disease. Arch Neurol 1987;44:24–9.

19. Tison F, Dartigues JF, Dubes L, et al. Prevalence of Parkinson’s
disease in the elderly: a population study in Gironde, France.
Acta Neurol Scand 1994;90:111–15.

20. Letenneur L, Gilleron V, Commenges D, et al. Are sex and educational
level independent predictors of dementia and Alzheimer’s
disease? Incidence data from the PAQUID Project. J
Neurol Neurosurg Psychiatryr 1999;66:177–83.

21. Korn E, Graubard B, Midthune D. Time-to-event analysis of
longitudinal follow-up of a survey: choice of the time-scale.
Am J Epidemiol 1997;145:72–80.

22. Commenges D, Letenneur L, Joly P, et al. Modelling age-specific
risk: application to dementia. Stat Med 1998;17:1973–88.

23. Elbaz A, Bower J, Maraganore D, et al. Risk tables for parkinsonism
and Parkinson’s disease. J Clin Epidemiol 2002;55:25–31.

24. Launer L, Andersen K, Dewey M, et al. Rates and risk factors
for dementia and Alzheimer’s disease: results from EURODEM
pooled analyses. EURODEM Incidence Research Group
and Work Groups. Neurology 1999;52:78–84.