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Major Depression and Thyroid-Stimulating Hormone
   
CITATION:  Berlin, I., Lemonine, A., et al.  (2004). Should Major Depression with 'High Normal' Thyroid-Stimulating Hormone Be Treated Preferentially with Tricyclics?  Neuropsychobiology; 50, 2.

ABSTRACT:  In a prospective and naturalistic setting, two samples representing 209 depressed inpatients were assessed for thyroid functioning at admission before antidepressant treatment, and for depression before and after 1 month of antidepressant treatment. We hypothesized that se-rum thyroid-stimulating hormone (TSH) elevation >_ up-per 25th percentile of the normal reference range is associated with poorer response to antidepressant therapy and differences between tricyclic antidepressants (TCA) and other antidepressants. Screening for mild thyroid failure defined as serum TSH concentrations >_ upper 25th percentile of the normal range may provide clues to the clinician. Such patients have a more severe form of depression and a slower or impaired response to antidepressant therapy. It is also possible that they would benefit preferentially from TCA rather than other antidepressants.

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