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Neuropsychiatric Manifestations of Altered Thyroid State

CITATION:  Denicoff, K.D., Joffe, R.T., et al.  (1990).  Neuropsychiatric Manifestations of Altered Thyroid State.  Am J Psychiatry; 147:94-99.

ABSTRACT:  The authors assessed the mood and cognitive effects of sequential T4, T3, and withdrawal of thyroid hormone replacement on 2S patients who had had thyroidectomies for thyroid cancer. The patients experienced increased sadness and anxiety when they were without medication, but no significant difference in mood was noted between T4 and T3. The patients who experienced increased affective symptoms when not taking medication were more likely to have histories of affective illness or mood lability.

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