CENTER ON BEHAVIORAL MEDICINE

BODY-MIND CONNECTION

DISEASE

Disease:  Research Article

Disease Menu

CSF Transthyretin in Patients with Depression

CITATION:  Hatterer, J.A., Herbert, J., et al. (1993). CSF Transthyretin in Patients With Depression. Am J Psychiatry 1982; 139:34-38.

ABSTRACT:   Some depressed patients may suffer from restricted central hypothyroidism, which could occur if levels of the thyroid hormone transport protein transthyretin were low. CSF transthyretin was measured in eight inpatients with refractory major depression and nine neurological patients. The depressed patients had significantly lower transthyretin levels than the comparison subjects, suggesting that central hypothyroidism, with normal peripheral thyroid concentrations, could occur in some depressed patients.

References

1. Gold MS, Pottash ALC, Extein IL: "Symptomless" autoimmune thyroiditis in depression. Psychiatry Res 1988; 6:261-269

2. Nemeroff CB, Simon JS, Haggerty JJ Jr, Evans DL: Antithyroid antibodies in depressed patients. Am J Psychiatry 1985; 142: 840-843

3. Goodwin FK, Prange AJ Jr, Post RM, Muscettola G, Lipton MA: Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders. Am J Psychiatry 1982; 139:34-38

4. Banki CM, Bissette G, Arato M, Nemeroff CB: Elevation of immunoreactive CSF TRH in depressed patients. Am J Psychiatry 1988;145:1526-1531

5. Loosen PT, Prange AJ Jr: Serum thyrotropin response to thyrotropin-releasing hormone in psychiatric patients: a review. Am J Psychiatry 1982; 139:405--416

6. Herbert J, Wilcox JN, Pham KC, Fremeau RT, Zeviani M, Dwork A, Soprano DR, Makover A, Goodman DS, Zimmerman EA, Roberts JL, Schon EA: Transthyretin: a choroid plexus-specific transport protein in human brain. Neurology 1986; 36: 900-911
Am J Psychiatry 150:5, May 1993

7. Schreiber G, Aldred A,Jaworoski A, Nilsson C, Achen MG, Segal MB: Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus. Am J Physiol 1990; 258(2, part 2):R338-R345

8. Spitzer RL, Williams JBW, Gibbon M: Structured Clinical Inter-view for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1987

9. Axelsen NH, Kroll J, Weeke B (eds): A Manual of Quantitative
Immunoelectrophoresis. Oslo, Universitetsforlaget, 1973, pp 47-56

10. Gewirtz GR, Malaspina D, Hatterer JA, Feureisen S, Klein D, Gorman JM: Occult thyroid dysfunction in patients with refractory depression. Am J Psychiatry 1988; 145:1012-1014

11. Bauer MS, Whybrow PC, Winokur A: Rapid cycling bipolar affective disorder, I: association with grade I hypothyroidism. Arch Gen Psychiatry 1990; 47:427-432