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Thyroid Hormone Levels and Recurrence of Major Depression

CITATION:  Joffe, R.T. and Marriott, M.  (2000). Thyroid Hormone Levels and Recurrence of Major Depression. Am J Psychiatry 2000, 157:1689-1691


Objective: The relationship between basal thyroid hormone levels and acute antidepressant response has been studied, but any relationship between basal thyroid hormone levels and long-term course of depressive illness has not been evaluated.

Method: The authors used a Cox regression survival analysis to evaluate the relationship between life course of depressive illness and basal levels of thyroid hormones (triiodothyronine [T3], thyroxine [T4,], and thyrotropin) in 75 outpatients with unipolar major depressive disorder.

Results: Time to recurrence of major depression was inversely related to T3 levels but not to T4 levels.
Conclusions: These data may be of clinical interest in view of the fact that T3 is used to augment antidepressant response.


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